Expression and Function of COX Isoforms in the Renal Medulla: Evidence for Regulation of Salt Sensitivity and Blood Pressure
نویسندگان
چکیده
Running title: Renal medullary COX-1 and -2 in Bp control Address all correspondence to: Tianxin Yang, M.D., Ph.D. University of Utah and VA Medical Center Bldg 2, Research Service (151 E) 500 Foothill Drive Salt Lake City, UT 84148 Tel: 801-582-1565 Ext 4334 Fax: 301-584-5658 Email: [email protected] Articles in PresS. Am J Physiol Renal Physiol (September 27, 2005). doi:10.1152/ajprenal.00232.2005
منابع مشابه
Expression and function of COX isoforms in renal medulla: evidence for regulation of salt sensitivity and blood pressure.
Expression of cyclooxygenase (COX)-2, but not COX-1, in the renal medulla is stimulated by chronic salt loading; yet the functional implication of this phenomenon is incompletely understood. The present study examined the cellular localization and antihypertensive function of high-salt-induced COX-2 expression in the renal medulla, with a parallel assessment of the function of COX-1. COX-2 prot...
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Many enzymes that produce natriuretic factors such as nitric oxide synthase (NOS), hemeoxygenase-1 (HO-1) and cyclooxygenase-2 (COX-2) are highly expressed in the renal medulla. These enzymes in the renal medulla are up-regulated in response to high salt intake. Inhibition of these enzymes within the renal medulla reduces sodium excretion and increases salt sensitivity of arterial blood pressur...
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Prostaglandins (PGs) are important autocrine/paracrine regulators that contribute to sodium balance and blood pressure control. Along the nephron, the highest amount of PGE2 is found in the distal nephron, an important site for fine-tuning of urinary sodium and water excretion. Cylooxygenase-2 (COX-2) is abundantly expressed in the renal medulla and its expression along with urinary PGE2 excret...
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The present studies were undertaken to determine the effect of dietary salt intake on the renal expression of cyclooxygenase-1 (COX-1) and -2 (COX-2). Protein levels were assessed by Western blotting, and mRNA expression was assessed by reverse transcription-polymerase chain reaction (RT-PCR) on cDNA prepared from kidney regions, dissected nephron segments, and cultured renal cells. Both isofor...
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BACKGROUND In response to high salt intake, transcription factor hypoxia-inducible factor (HIF) 1α activates many antihypertensive genes, such as heme oxygenase 1 (HO-1) 1 and cyclooxygenase 2 (COX-2) in the renal medulla, which is an important molecular adaptation to promote extra sodium excretion. We recently showed that high salt inhibited the expression of HIF prolyl-hydroxylase 2 (PHD2), a...
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